Search results for "Interstitial space"
showing 9 items of 9 documents
Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance.
2000
The metabolic microenvironment of a tumor is predominantly determined by the efficacy of blood flow, flux parameters (such as diffusion and convective currents in the interstitial space) and metabolic rates. The most important factors in this context include oxygen and nutrient supply, tissue pH and the bioenergetic status. It is now widely accepted that the metabolic microenvironment of a tumor can dramatically influence a range of factors such as proliferation rate, cell cycle position, growth rate and the development of apoptosis and necrosis. At the same time, these parameters can have an impact on tumor detection, therapeutic response to conventional irradiation, some chemotherapy agen…
Microvascular injury and repair in acute human bacterial pyelonephritis.
1987
Acute inflammatory cell-capillary endothelial cell interactions, related to injury and repair, were investigated light and electron microscopically in acute human bacterial pyelonephritis. In inflammatory infiltrate-adjacent microvessels, the small capillaries were completely occluded by leukocyte plugs and the large capillaries were densely filled with acute inflammatory cells adhering to the endothelium. Severe damage to small and large capillaries was observed around endothelium adherent, degranulated neutrophil granulocytes containing phagocytosed bacteria. There were spaces in the endothelium, degradation of the vascular basement membrane, of the perivascular interstitial matrix and of…
Ultrastructural study on human lung in alveolitis versus pulmonary fibrosis
1993
Lung specimens of 21 patients with diffuse interstitial lung disease were examined. The present ultrastructural study outlines the topography and distribution of inflammatory changes in the interstitium, endothelium, and in pneumocytes and phagocytes. Alveolitis is characterized by marked regenerative activity of type II pneumocytes (cuboid metaplasia), intraluminal macrophage accumulation, endothelial swelling, multilamination of the endothelial basement membrane, pericapillary edema, and primarily by cellular infiltrates in the interstitial space. The most prominent feature of the interstitium in pulmonary fibrosis is the lack of immunoinflammatory cells. In some areas there is a marked a…
P863Morphometric analysis of the dynamic changes of the interstitium after reperfused myocardial infarction
2019
Abstract Background The interstitial space is mainly composed by cells, fibers and gels of polysaccharides, which act as a compression buffer against the stress placed on the extracellular matrix (ECM). After myocardial infarction (MI), heart has to withstand higher mechanical stress due to injured cardiomyocytes. ECM composition notably influences the mechanical properties of the myocardium and participates in left ventricular remodeling. Purpose To characterize the myocardial ECM changes from ischemia onset until late phases after coronary reperfusion in a swine model of reperfused MI. Methods MI was induced in swine by transient 90-min coronary occlusion using angioplasty balloons. One c…
Morphology of follicle cells of Libellulidae (Odonata)
2011
In libellulids, mature oocyte size varies within and between individual ovaries. The regulating mechanism is not yet understood. Variations in the contents of the follicle cells, and thereby their ability to secrete material into the oocyte, might explain some of the observed differences in oocyte size. We therefore investigated the follicle cell surface, the interstitial space width between follicle cells and between follicle cells and oocytes, the number of nuclei, and the cell compartment proportions using scanning and transmission electron microscopy. In all investigated species, the follicle cells were covered by a basal lamina. We found cytoplasmic microvilli and septate junctions. As…
Absorption And Transferring Of The Coghlear Fluids
1968
The perilymph is absorbed in the loose connective tissue of the modio-lum, the endolymph is absorbed in the planum limbi and the interstitial liquid of the organ of Corti in the inner spiral sulcus. The basin of the vein of the aqueduct of the cochlea in a fetal phase transfers almost only perilymph. When fully developed, many veins of the above-said basin are obliterated and the remaining ones transfer more blood than perilymph. From the interstitial spaces of the limbus the endolymph flows into the capillaries towards the inner auditory veins and the interstitial liquid of the organ of Corti flows towards the same veins by means of short lymphatic vessels.
Physiological Mechanisms of Treatment Resistance
2009
It is generally accepted that tumor perfusion, microcirculation, characteristics of the interstitial space of tumors, oxygen (and nutrient) supply, tissue pH distribution and the bioenergetic status—factors that are usually closely linked and that define the so-called pathophysiological microenvironment—can markedly influence the therapeutic response of malignant tumors to sparsely ionizing radiation, chemotherapy, photodynamic therapy, hormonal therapy and immunotherapy. Besides more direct mechanisms involved in the development of acquired therapeutic resistance, there are in addition, obstacles in intratumor pharmacokinetics of antitumor agents due to delivery problems caused by an inade…
Tenascin in denervated human muscle
1996
Tenascin is a large oligomeric glycoprotein of the extracellular matrix. Its location is limited in innervated muscle tissues. We investigated immunohistologically, using two monoclonal antibodies (mab) against Tenascin, biopsied denervated human muscle of children and adults. Tenascin was present in the interstitial space among denervated muscle fibres. Accumulation of Tenascin in denervated adult muscle tissue was frequent, accumulation in denervated muscle tissue of children was sparse and weak. The two antibodies reacted correspondingly. Tenascin was not only found in the vicinity of atrophic muscle fibres, but also close to normally sized fibres, suggesting an early stage of denervatio…
Interstitial washout and hydrolysis of acetylcholine in the perfused heart
1982
The efflux of acetylcholine, of radioactively labelled acetylcholine and choline, into the venous effluent of the perfused chicken heart was studied to determine the kinetics of both interstitial washout and hydrolysis of acetylcholine. Stimulation of both cervical vagus nerves (e.g., for 5 s at 40 Hz) caused a release of acetylcholine, which appeared partially unhydrolyzed in the venous effluent, and reduced force of contraction and heart rate. For comparison, labelled acetylcholine or choline was infused for 5 s into the heart and again the venous efflux of either substance was determined. It was found that the kinetics of efflux of acetylcholine or choline from the interstitial space wer…